Myostatin inhibition improves hyperglycemia and hyperphagia in lipodystrophic mice
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Myostatin inhibition improves hyperglycemia and hyperphagia in lipodystrophic mice
Background Skeletal muscle is a key peripheral metabolic tissue: Muscle is responsible for most insulin-stimulated glucose uptake, and muscle insulin resistance is the first defect detectable in the development of type 2 diabetes. Recent studies show that muscle mass is inversely correlated with insulin resistance in humans. The growth factor myostatin (MSTN) is a negative regulator of skeletal...
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Lipodystrophies are characterized by a loss of white adipose tissue, which causes ectopic lipid deposition, peripheral insulin resistance, reduced adipokine levels, and increased food intake (hyperphagia). The growth factor myostatin (MSTN) negatively regulates skeletal muscle growth, and mice with MSTN inhibition have reduced adiposity and improved insulin sensitivity. MSTN inhibition may ther...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2012
ISSN: 1753-6561
DOI: 10.1186/1753-6561-6-s3-p7